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Evaluating confidence in analytical measurement: Experiments to Assess the Effects of Grinding/Milling Time on the Determination of dimetridazole in Animal Feeding Stuffs
Laboratories frequently receive samples of an agglomerated particulate nature for analysis. These samples, for example soils or animal feeds, require some form of preparation before an appropriate technique can be applied to detect or quantify the analyte of interest. One common approach is to grind or mill the material so that it passes through a sieve of specified aperture. This enables the material to be more readily homogenised by mixing before a test portion is extracted for analysis.
It might be expected that results obtained on ground material would be sensitive to grinding time. Longer grinding times may lead to a greater production of fines and/or thermal degradation of the analyte. Grinding/milling therefore constitutes a source of uncertainty. In order to gain an idea of the magnitude of this uncertainty a series of experiments was carried out on a sample of medicated pelleted animal feed. The feed contained approximately 100mg kg-1 of dimetridazole and the experiments were designed to assess the effect of grinding on the subsequent determination of this compound.
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